In the heart of Africa, on the banks of the River, a mysterious epidemic breaks out, threatening the entire animal world. The only one capable of confronting the unknown disease is Dr. Dolittle. Without wasting a moment, he embarks on a journey with his loyal dog Woofie and new friends. Ahead of them lie wild jungles, dangerous crossings, and thrilling chases.
They soon discover that the epidemic is part of a sinister scheme by the cunning pirate Barm’o’Ley, who exploits the suffering of others for his own gain and kidnaps sick animals. Now Dr. Dolittle faces an even greater challenge: not only to cure the animals, but also to save the entire animal kingdom. Will the famous doctor be able to defeat Barm’o’Ley, save hundreds of animals, and bring them safely home?